FUNCTIONAL VALIDATION: THE OMEGA-NMJ-ON-A-CHIP™ PLATFORM IN ACTION
Mature 3D tissue. Robust functional activity.
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Below is the functional validation of the individual tissues cultured within our proprietary OMEGA-NMJ-on-a-chip™ platform. These visuals demonstrate the highly active neuronal networks and the mature 3D skeletal muscle contractility that form the foundation of our zero-crosstalk assays.
VIDEO 1: Robust Functional Activity — iPSC-derived Motor Neurons
Loaded with a calcium indicator, these cells exhibit distinct calcium transients upon electrical stimulation. Notice the clear extension of healthy axons into the highly restrictive microchannels, demonstrating the exceptional network viability and signaling capability required to drive our zero-crosstalk assays.
VIDEO 2: Mature 3D Muscle Tissue — Primary Skeletal Muscle Contractility
Cultured within the proprietary eNUVIO device, this primary 3D microtissue displays the synchronized contractile properties expected of fully developed skeletal muscle. This strong functional response to electrical stimulation highlights the advanced structural integrity and maturity supported by the platform's architecture.
Partner with eNUVIO for Custom R&D Services
Achieving this level of 3D tissue maturity and microfluidic precision is highly specialized. Instead of troubleshooting in-house, we partner with biotechs and pharma to run complex, interconnected NMJ screens and custom assays for them end-to-end.
Our deliverables include:
- Localized toxicity & strict compartment-specific dosing
- Functional readouts (e.g., IC50, EC50, longitudinal live-cell imaging)
- Phenotypic profiling
Partner with eNUVIO for Custom R&D Services
Achieving this level of 3D tissue maturity and microfluidic precision is highly specialized. Instead of troubleshooting in-house, we partner with biotechs and pharma to run complex, interconnected NMJ screens and custom assays for them end-to-end.
Our deliverables include:
- Localized toxicity & strict compartment-specific dosing
- Functional readouts (e.g., IC50, EC50, longitudinal live-cell imaging)
- Phenotypic profiling
