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High-Throughput Screening Compatible
Each chamber of the OMEGA96-MP device contains two built-in micropillars that serve to form 3D skeletal muscle microtissues in vitro. Myogenic progenitor cells from primary, iPSC or immortalized sources are resuspended in an ECM-derived hydrogel mixture, and are seeded into each culture chamber. After polymerization, the hydrogel-suspended myoblasts begin to differentiate and self-assemble into a 3D muscle microtissue using the two micropillars as anchors. Once sufficiently matured, these microtissues twitch and contract as you would expect from skeletal muscle.
The ability to examine the contractile and electrophysiological characteristics of mature skeletal muscle is incredibly advantageous in the context fundamental as well as drug development research. The OMEGA96-MP is the ideal platform for the development of next-generation models of muscle and neuromuscular disorders such as Duchenne-type muscular dystrophy (DMD), Kennedy’s disease (SBMA) as well as ALS.
This next-generation microplate is fully adapted to the standard 96-well microplate format, and is compatible with automated lab equipment. Each OMEGA96-MP screening plate contains 96 individual chambers. The thin and optically clear PDMS base has low auto-fluorescence. High-resolution images of the generated muscle microtissues can be recorded with ease using plate readers and high-content screening platforms.
OMEGA96-MP plates are shipped sterile; simply treat each chamber with an anti-fouling coating and seed your cells.
Maintaining healthy cultures over a long period of time is even easier with eNUVIO’s microplates, owing to the evaporation-minimizing tracks around the edge of each plate.
- iPSC-derived myogenic precursors
- Primary cells (biopsy)
- Immortalized myogenic cell lines
- 96 well microplate = 96 individual experiments per plate
- Microplate structure material: Polydimethylsiloxane (PDMS), biologically inert
- Microplate outer dimensions: 127.7 x 85.4 mm
- Microplate height (w/o lid): 14.2 mm
- Chamber pitch: 9 mm
- Shipped sterile and ready-to-go
- Anti-evaporation tracks around the edge of each plate
- Equivalent to 12 OMEGAMP kits, at a fraction of the price