PRODUCT OVERVIEW

Our OMEGA double-chamber microfluidic devices are perfectly suited for experiments involving neuronal co-culture and compartmentalization.

The unique design requires only two chambers per experiment, effectively doubling the number of experiments per area compared to conventional co-culture devices.

Each set of two culture chambers are physically separated by a series of microfluidic channels. The small size of the microchannels serve to fluidically isolate each of the adjoined chambers, but are large enough to allow neurites/axons to project into and interact with cultures located in the adjacent chamber.

OMEGA devices feature identical culture chambers on either side of the microchannels and are available in 4-well and 96-well format.
The OMEGA^4-2mini and OMEGA^4-2mini-2mm feature smaller chambers on one side of the microchannel so you can save on cells and culture media. They are both available in 4-well format.

Our OMEGA^ACE devices each contain three serially-adjoined culture chambers, providing researchers with the ability to perform more specialized experiments.

OMEGA^ACE devices can be used for in vitro triple co-culture studies of neurodegeneration, neuromuscular junction (NMJ), nigrostriatal pathway, pain, myelination, or chemotactic factors. They also suit themselves for studying neuronal propagation of toxic or misfolded proteins! In single culture applications, the OMEGA^ACE can serve as a compartmentalization tool to separate the somatic, proximal axonal and distal axonal (growth cone) components of neurons.

Available in four different formats with differently sized middle chambers.

We designed the OMEGA^AG device to help researchers study axon guidance and chemotactic factors in vitro.

The device has 4 chambers that are each connected to a central viewing area via a series of microchannels. The flow of fluid across the microchannels can be controlled by simply adjusting the relative fluid volumes in each of the chambers. This asymmetric volume loading of the chambers can serve to fluidically isolate adjacent chambers (like for our original OMEGA device), but can also be used to control the direction of flow into and out from the viewing area.

We designed the OMEGA^NMJ specifically to best recapitulate neuromuscular synaptic physiology in vitro.

Motor neurons seeded in the neuronal culture chamber extend axons into the adjoined oval muscle chamber through a series of microchannels that serve to fluidically isolate the two culture chambers. This way, the somatic motor neuron components are not directly exposed to the 3D skeletal muscle they innervate, forming a system that more closely resembles the native neuromuscular physiology.

With each device, you can perform two individual experiments.

Looking to advance your skeletal muscle research projects using 3D cultures? Now you can easily access this exciting new culture technology using our OMEGA^MP devices.

Compared to monolayer muscle cultures that are known to detach from the surface after a short period of time, 3D skeletal muscle is stable for longer-term culture applications and matures more rapidly and completely. This increased physiological relevance of this system makes it ideal for the development of new disease models of both muscle and neuromuscular disorders.

Available in 2-well and 96-well format.

This product is discontinued and has been replaced by the EB-CLARIFY.

Generate, process, assay and image spheroids without having to manipulate or transfer - and potentially damage - the delicate 3D cultures! All in a single HTS-compatible microplate: the EB-CLARIFY!

Microfluidic channels between the round bottom spheroid chamber and the solution exchange chamber limit the intensity of solution exchange to protect the integrity of delicate spheroids/organoids. 

No more damaged or lost spheroids!

We offer a variety of accessories for our products.

Do you need to centrifuge your EB-DISK or want to inspect your OMEGA device under the microscope? For your convenience, we designed the right adapters for the most commonly used setups. 

Your dream microfabricated tool or technology does not exist yet?

Let us help you create your custom product so that you can push the boundary of what is currently possible.